TwistedNano targets the EU priority area “Health and Safety” by developing a set of new-generation ultrasensitive LOC-integrable photonic sensors of chiral drugs. Our optical technologies, capable of measuring AC and enantiomeric purity, will revolutionize at-source the sensing technological toolbox for drug discovery and nanomedicine. The envisioned devices will provide radically new and advanced capabilities for (i) remote & distributed analysis, (ii) reduced sample consumption, (iii) cost reduction, (iv) parallelization, (v) increased speed and sensitivity, crucial for fast clinical trials.